Sickle cell anemia and its impact on the oral cavity - Integrative review

Authors

Fernanda Leal, University Fernando PessoaFollow
Maria Inês Guimarães, Universidade Fernando PessoaFollow
Ambre NatbethFollow
Inês Lopes Cardoso, University Fernando PessoaFollow

DOI

https://doi.org/10.70174/iajd.v16i2.1491

Abstract

Sickle cell anemia, an hereditary disease, results from a mutation in the β-globin coding gene that makes up hemoglobin, leading to the deformation of erythrocytes. Numerous oral manifestations result from this disease, however, some may not be specific. Nevertheless, it is important to recognize these clinical manifestations of the disease to be able to manage oral health in sickle cell anemia patients.

Therefore, this integrative review analyzes scientific literature on the impact of sickle cell anemia on oral cavity. A bibliographic search was performed in PubMed, B-On and ScienceDirect databases using several combined keywords. The research question was: “What is the impact of sickle cell anemia on the oral cavity and dental treatments?”. By applying the inclusion and exclusion criteria, 11 articles were included in this review. Studies show that the most common oral manifestations in these patients are periodontal disease and caries, although this association is not well understood.

Recommended Citation

Leal, Fernanda; Guimarães, Maria Inês; Natbeth, Ambre; and Lopes Cardoso, Inês (2025) "Sickle cell anemia and its impact on the oral cavity - Integrative review," International Arab Journal of Dentistry: Vol. 16: Iss. 2, Article 14.
DOI: https://doi.org/10.70174/iajd.v16i2.1491
Available at: https://e-journals.usj.edu.lb/iajd/vol16/iss2/14