Efficacy of Autologous Platelet Rich Fibrin (PRF) in Promoting Soft Tissue Hеаling and Bоnе Rеgеnеrаtiоn following extraction in the Аntеriоr Maxilla: А digital and radiological study

Authors

Anthony El Rai, Saint Joseph's UniversityFollow
Abdallah Menhall, Saint Joseph UniversityFollow
Joseph Zaarour, Saint Joseph UniversityFollow
Robin Jalkh, Saint Jospeh UniversityFollow
Joseph Bassil, Saint Joseph UniversityFollow

DOI

https://doi.org/10.70174/iajd.v16i2.1478

Abstract

Objectives: The main objective of this study was to evaluate the effectiveness of PRF in promoting soft tissue healing and bone regeneration after extraction in the anterior maxillary region. A secondary objective is to correlate soft tissues change with underlying bone structure variation. Finally, the study also aimed to compare soft and hard tissue alteration based on different types of extracted teeth.

Materials and Methods: The sample included five adult patients requiring the extraction of at least two symmetrical teeth in the anterior maxilla, totaling fourteen teeth. Participants underwent CBCT scans and digital impressions before extraction. Concerned teeth were then extracted, and extraction sites were randomly assigned either to the experimental group (PRF) or the control group (without PRF). Ten weeks after extraction, follow-up CBCT scans and digital impressions were performed. The evaluation of soft and hard tissue changes was carried out by superimposing and aligning preoperative and postoperative CBCT scans and STL files.

Results: After ten weeks of healing, the study revealed an increase in soft tissue thickness of 38% and 34% at 2 mm and 4 mm, respectively, for the control group. As for the experimental group, soft tissue thickness increased 18% and 22%. Regarding hard tissues, the control group showed resorption of 33% and 25% at 2 mm and 4 mm respectively, while the experimental group showed resorption rates of 23% and 22%. The central incisor exhibited the highest hard tissue resorption, followed by the canine, while the first premolar showed the least resorption.

Conclusion: Within the limitations of this study, we observed better dimensional changes in hard tissues and soft tissue healing after extraction in the group where PRF was applied.

Keywords: Tooth Extraction, Platelet-Rich Plasma, Bone Remodeling, Clinical Trial, Wound Healing, Maxilla Imaging, Three-Dimensional Tomography, X-Ray Computed, Soft Tissue Injuries.

Recommended Citation

El Rai, Anthony; Menhall, Abdallah; Zaarour, Joseph; Jalkh, Robin; and Bassil, Joseph (2025) "Efficacy of Autologous Platelet Rich Fibrin (PRF) in Promoting Soft Tissue Hеаling and Bоnе Rеgеnеrаtiоn following extraction in the Аntеriоr Maxilla: А digital and radiological study," International Arab Journal of Dentistry: Vol. 16: Iss. 2, Article 1.
DOI: https://doi.org/10.70174/iajd.v16i2.1478
Available at: https://e-journals.usj.edu.lb/iajd/vol16/iss2/1